Effect of Zinc Supplement on Improvement of Homostatus Glucose in Thalassemia Major and Intermedia with Zinc Deficiency

Effect of Zinc Supplement on Improvement of Homostatus Glucose in Thalassemia Major and Intermedia with Zinc Deficiency in Yasuj, Iran, in 2019

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190301042871N1

Enrollment

106

Registered

2019-05-29

Start date

2019-04-20

Completion date

Unknown

Last updated

2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Homostatus Glucose Disorder in Thalassemia Major and Intermedia with Zinc Deficiency.

Interventions

Intervention 1: Intervention group: one group of patients are given oral zinc with dose of 1 mg to 2 mg / kg / day with a maximum dose of 50 mg / day for 6 months, to improve the drug and reduce the

Eligibility

Sex/Gender

All

Age

10 Years to No maximum

Inclusion criteria

Inclusion criteria: Thalassemic patients and Intermedia (confirmed with hemoglobin electrophoresis) Age greater than 10 years Patients with glucose homeostasis disorder Patients with zinc deficiency

Exclusion criteria

Exclusion criteria: Thalassemic patients with diabetes mellitus Glycemic control drugs 3- Liver failure

Design outcomes

Primary

Measure	Time frame
Serum Zinc Level,Glucose Homeostasis Disorder. Timepoint: Begining of study and after 6 month. Method of measurement: - Blood serum glucose with the method,glucose oxidase and glucose peroxidase with kits of Pars Azmon Company - Insulin serum and C- peptide with Eliza method and with MonoBand Company kit - serum zinc level with atomic absorption method.	—

Secondary

Measure	Time frame
1) Insolinogenic index (evaluation of pancreatic beta cell function) 2) Insulin sensitivity & insulin resistant index 3)Impaired Fasting Glucose 4)Impaired glucose tolerance. Timepoint: Begining study and after 6 mont. Method of measurement: Fasting plasma glucose and serum glucose levels two hours after breakfast are measured with glucose oxidase and glucose peroxidase with the kits of Pars Azmon Company. Insulin and serum C-peptide are measured by the Eliza method and monobandin kits. The serum zinc is measured by atomic absorption method.	—

Measure

Time frame

1) Insolinogenic index (evaluation of pancreatic beta cell function) 2) Insulin sensitivity & insulin resistant index 3)Impaired Fasting Glucose 4)Impaired glucose tolerance. Timepoint: Begining study and after 6 mont. Method of measurement: Fasting plasma glucose and serum glucose levels two hours after breakfast are measured with glucose oxidase and glucose peroxidase with the kits of Pars Azmon Company. Insulin and serum C-peptide are measured by the Eliza method and monobandin kits. The serum zinc is measured by atomic absorption method.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSomayeh Zeraati Zardkhoni

Yasouj University of Medical Sciences

dr.zeraati@gmail.com+98 74 3322 0162

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026