Evaluation the effect of endurance training and MitoQ supplementation on blood pressure

Evaluation the effect of four weeks endurance training and MitoQ supplementation alone and in combination on serum level of some of microRNAs effective on blood pressure and oxidant, antioxidant, inflammatory and on functional cardiac factors in hypertensive patients

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190228042870N1

Enrollment

Registered

2019-04-17

Start date

2019-04-21

Completion date

Unknown

Last updated

2019-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension. Hypertensive diseases

Interventions

Intervention 1: Control group: Hypertension: People in this study have a systolic blood pressure equal to or greater than 140 mm Hg and a diastolic blood pressure equal to or greater than 90 mm Hg. Du

Hypertension group with endurance training: In this group, people with hypertension for 4 weeks (3 times a week), exercise endurance bike with specified strength and depending on the aerobic capacity.

Eligibility

Sex/Gender

Male

Age

40 Years to 55 Years

Inclusion criteria

Inclusion criteria: systolic blood pressure > 140 mmHg Diastolic pressure > 90 mmHg

Exclusion criteria

Exclusion criteria: Liver, kidney, lung, diabetes diseases and certain diseases like cancer

Design outcomes

Primary

Measure	Time frame
MiR-21. Timepoint: At the beginning of the study (before the intervention) and 28 days after taking the MitoQ supplement or performing endurance training. Method of measurement: Real-Time PCR.;MiR-27a. Timepoint: At the beginning of the study (before the intervention) and 28 days after taking the MitoQ supplement or performing endurance training. Method of measurement: Real-Time PCR.;MiR-126. Timepoint: At the beginning of the study (before the intervention) and 28 days after taking the MitoQ supplement or performing endurance training. Method of measurement: Real-Time PCR.;MiR-222. Timepoint: At the beginning of the study (before the intervention) and 28 days after taking the MitoQ supplement or performing endurance training. Method of measurement: Real-Time PCR.;Blood pressure. Timepoint: before the intervention and Days 1, 3, 5, ... and 28th day. Method of measurement: Sphygmomanometer.;Percentage of arterial oxygen saturation. Timepoint: Before training, during training, immediately after training and at intervals of 15, 30 and 45 minutes after training. Method of measurement: Pulse Oximeter.;HDL-c. Timepoint: before the intervention and Days 14 and 28. Method of measurement: Biochemical autoanalyzer.;Oxidized LDL. Timepoint: before the intervention and 28th day. Method of measurement: Elisa kit.;Cholestrol. Timepoint: before the intervention and Days 14 and 28. Method of measurement: Biochemical autoanalyzer.;Triglyceride. Timepoint: before the intervention and Days 14 and 28. Method of measurement: Biochemical autoanalyzer.;Heart rate. Timepoint: Before training, during training, immediately after training and at intervals of 15, 30 and 45 minutes after training. Method of measurement: Pulse Oximeter.;Left Ventricular End-Systolic Diamater. Timepoint: before the intervention and 28th day. Method of measurement: Echocardiography.;Left Ventricular End-diastolic Diamater. Timepoint: before the intervention and 28th day. Method of measurement: Echocardiography.;Ej	—

Measure

Time frame

MiR-21. Timepoint: At the beginning of the study (before the intervention) and 28 days after taking the MitoQ supplement or performing endurance training. Method of measurement: Real-Time PCR.;MiR-27a. Timepoint: At the beginning of the study (before the intervention) and 28 days after taking the MitoQ supplement or performing endurance training. Method of measurement: Real-Time PCR.;MiR-126. Timepoint: At the beginning of the study (before the intervention) and 28 days after taking the MitoQ supplement or performing endurance training. Method of measurement: Real-Time PCR.;MiR-222. Timepoint: At the beginning of the study (before the intervention) and 28 days after taking the MitoQ supplement or performing endurance training. Method of measurement: Real-Time PCR.;Blood pressure. Timepoint: before the intervention and Days 1, 3, 5, ... and 28th day. Method of measurement: Sphygmomanometer.;Percentage of arterial oxygen saturation. Timepoint: Before training, during training, immediately after training and at intervals of 15, 30 and 45 minutes after training. Method of measurement: Pulse Oximeter.;HDL-c. Timepoint: before the intervention and Days 14 and 28. Method of measurement: Biochemical autoanalyzer.;Oxidized LDL. Timepoint: before the intervention and 28th day. Method of measurement: Elisa kit.;Cholestrol. Timepoint: before the intervention and Days 14 and 28. Method of measurement: Biochemical autoanalyzer.;Triglyceride. Timepoint: before the intervention and Days 14 and 28. Method of measurement: Biochemical autoanalyzer.;Heart rate. Timepoint: Before training, during training, immediately after training and at intervals of 15, 30 and 45 minutes after training. Method of measurement: Pulse Oximeter.;Left Ventricular End-Systolic Diamater. Timepoint: before the intervention and 28th day. Method of measurement: Echocardiography.;Left Ventricular End-diastolic Diamater. Timepoint: before the intervention and 28th day. Method of measurement: Echocardiography.;Ej

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactYaser Masoumi-Ardakani

Kerman University of Medical Sciences

ymab125@gmail.com+98 34 3223 6839

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 11, 2026