The Effect of Combined Pain Neuroscience Education and Comprehensive Neuromuscular Training on Knee Osteoarthritis

The Effect of Adding Pain Theory Education to Comprehensive Neuromuscular Exercise on Pain, Range of Motion, Posture Control and Electromyographic Activity of Knee Muscles in Women with Knee Osteoarthritis

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190224042827N6

Enrollment

Registered

2025-11-12

Start date

2025-11-22

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of knee. Osteoarthritis of knee, unspecified

Interventions

Intervention 1: Intervention group: Participants in this group will receive a combined program of neuromuscular training and pain neuroscience education. The neuromuscular training will be conducted f

Eligibility

Sex/Gender

Female

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: Unilateral or bilateral knee osteoarthritis (diagnosed by a physician) No intra-articular steroid injection in the past six months Onset of menopause Mild to moderate knee pain

Exclusion criteria

Exclusion criteria: Body mass index (BMI) greater than 30 kg/m² History of surgery or fracture of lower-limb joints within the past six months Presence of cardiovascular diseases Severe cognitive impairment

Design outcomes

Secondary

Measure	Time frame
Knee joint range of motion. Timepoint: Pre- and Post-test of 8 weeks intervention. Method of measurement: Universal goniometer.;Dynamic balance. Timepoint: Pre- and Post-test of 8 weeks intervention. Method of measurement: Timed Up and Go test.;Postural control. Timepoint: Pre- and Post-test of 8 weeks intervention. Method of measurement: Foot scan.;Lower limb muscle activity patterns. Timepoint: Pre- and Post-test of 8 weeks intervention. Method of measurement: EMG.	—

Measure

Time frame

Knee joint range of motion. Timepoint: Pre- and Post-test of 8 weeks intervention. Method of measurement: Universal goniometer.;Dynamic balance. Timepoint: Pre- and Post-test of 8 weeks intervention. Method of measurement: Timed Up and Go test.;Postural control. Timepoint: Pre- and Post-test of 8 weeks intervention. Method of measurement: Foot scan.;Lower limb muscle activity patterns. Timepoint: Pre- and Post-test of 8 weeks intervention. Method of measurement: EMG.

—

Primary

Measure	Time frame
Knee pain. Timepoint: Pre- and Post-test of 8 weeks intervention. Method of measurement: Visual Analogue Scale (VAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzane Ramezani

Bu Ali Sina University

f.ramezani@phe.basu.ac.ir+98 81 3838 1423

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026