The Effect of Propofol and Isoflurane on Hemodynamics Parameters and Stress Response Hormones during Laparoscopic Cholecystectomy

Comparison the Effect of Propofol and Isoflurane on Hemodynamics Parameters and Stress Response Hormones during Laparoscopic Cholecystectomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190222042806N1

Enrollment

Registered

2019-09-25

Start date

2019-08-23

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gallstone disease. Disease of gallbladder, unspecified

Interventions

Intervention 1: Intervention group (1): Intravenous injection of propofol 50-150 µg/kg/min is performed. Intervention 2: Intervention group (2): Isoflurane with mac: 1.28% atm/mmhg is vaporized and pa

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with symptomatic gallstone disease Patients with acute cholecystitis Patients without inside or outside biliary tract dilatation American Society of Anesthesiologists (ASA) classification I , II

Exclusion criteria

Exclusion criteria: Obesity patients with class II or III (BMI>35) Patients with chronic liver disease, diabetes, renal failure, endocrine problems, rheumatoid arthritis, cardiovascular disease or malignancy Patients receiving drugs with known effects on sympathetic response or hormone secretion such as Beta-blockers Patients receiving benzodiazepines Pregnant or lactating mothers

Design outcomes

Primary

Measure	Time frame
Mean arterial pressure (MAP(. Timepoint: Time of starting the operation, every 5 minutes during the time between start of surgery till the completion of the surgical operation and 20 minutes after attending to recovery room. Method of measurement: Gauge pressure.;Heart rate. Timepoint: Time of starting the operation, every 5 minutes during the time between start of surgery till the completion of the surgical operation and 20 minutes after attending to recovery room. Method of measurement: Electrocardiograph signal.;Epinephrine level. Timepoint: Before starting the operation (after anesthesia induction) and after finish running suturing (before reverse). Method of measurement: Blood test.;Blood glucose. Timepoint: Before starting the operation (after anesthesia induction) and after finish running suturing (before reverse). Method of measurement: Blood test.	—

Measure

Time frame

Mean arterial pressure (MAP(. Timepoint: Time of starting the operation, every 5 minutes during the time between start of surgery till the completion of the surgical operation and 20 minutes after attending to recovery room. Method of measurement: Gauge pressure.;Heart rate. Timepoint: Time of starting the operation, every 5 minutes during the time between start of surgery till the completion of the surgical operation and 20 minutes after attending to recovery room. Method of measurement: Electrocardiograph signal.;Epinephrine level. Timepoint: Before starting the operation (after anesthesia induction) and after finish running suturing (before reverse). Method of measurement: Blood test.;Blood glucose. Timepoint: Before starting the operation (after anesthesia induction) and after finish running suturing (before reverse). Method of measurement: Blood test.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactElham Shayda Golbad

Ahvaz University of Medical Sciences

elham.sh.golbad@gmail.com+98 61 3333 5935

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026