The effect of Nanodexamethasone permeation on uveitis

Comparison of the Effectiveness of Nano-Dexamethasone particles and Dexamethasone Drops 0.1% in the Control of Anterior Uveitis Patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190218042750N1

Enrollment

Registered

2019-06-21

Start date

2019-02-19

Completion date

Unknown

Last updated

2019-08-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior Uveitis. Acute and subacute iridocyclitis

Interventions

Intervention 1: Intervention group: Nano-dexamethasone group

Nano-Dexamethasone compounds with a concentration of 0.1% with fatty-based micellar carrier are first applied every 4 hours and based on the response to treatment, the intervals of drug use increase a

In this group, patients treated with 0.1% Dexamethasone eye drops receive at intervals of 4 hours at the start of the treatment and then, according to the response status to the treatment, the interva

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Having anterior uveitis Being acute case

Exclusion criteria

Exclusion criteria: Retina disease Patients with glaucoma Uveitis developed after ocular surgery Being recurrence of the disease Patients with inappropriate cooperation in admission of treatment

Design outcomes

Primary

Measure	Time frame
Best corrected visual acuity. Timepoint: Determine the best corrected visual acuity before treatment and days 3, 7, 14, 28, and the end of the second month. Method of measurement: Snellen chart is at a standard distance of 6 meters.;Intraocular pressure. Timepoint: Determine intraocular pressure of patients before treatment and days 3, 7, 14, 28, after starting treatment and the end of the second month. Method of measurement: Using a Goldman Tonometer based on a unit of mmHg.;Corneal edema. Timepoint: Measurement of the central corneal thickness of the cornea before the onset of treatment and on days 7 and 28 after the onset of treatment and the end of the second month after the start of treatment. Method of measurement: Using a topographic device based on a micro-meter unit.;The cellular response of the anterir chamber of the eye. Timepoint: Determine the amount of cellular response in the anterior chamber of the eye on the day before treatment and on days 3, 7, 14, 28, and the end of the second month after the start of treatment. Method of measurement: Based on the SUN-WORKING grading, it is characterized by degrees 0, 1, 2, 3, and 4.	—

Measure

Time frame

Best corrected visual acuity. Timepoint: Determine the best corrected visual acuity before treatment and days 3, 7, 14, 28, and the end of the second month. Method of measurement: Snellen chart is at a standard distance of 6 meters.;Intraocular pressure. Timepoint: Determine intraocular pressure of patients before treatment and days 3, 7, 14, 28, after starting treatment and the end of the second month. Method of measurement: Using a Goldman Tonometer based on a unit of mmHg.;Corneal edema. Timepoint: Measurement of the central corneal thickness of the cornea before the onset of treatment and on days 7 and 28 after the onset of treatment and the end of the second month after the start of treatment. Method of measurement: Using a topographic device based on a micro-meter unit.;The cellular response of the anterir chamber of the eye. Timepoint: Determine the amount of cellular response in the anterior chamber of the eye on the day before treatment and on days 3, 7, 14, 28, and the end of the second month after the start of treatment. Method of measurement: Based on the SUN-WORKING grading, it is characterized by degrees 0, 1, 2, 3, and 4.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMostafa Feghhi

Ahvaz University of Medical Sciences

mfeghhi@ajums.ac.ir+98 61 3222 2818

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026