The Effect of Pulsatile and Non-pulsatile Perfusion Flow on Renal Function during Coronary Artery Bypass Grafting Surgery in Patients with Left Ventricular Dysfunction

Comparison of the Effect of Pulsatile and Non-pulsatile Perfusion Flow on Renal Function during Coronary Artery Bypass Grafting Surgery in Patients with Left Ventricular Dysfunction

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190218042749N1

Enrollment

Registered

2019-07-15

Start date

2018-01-21

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who have Coronary Artery Disease candidate of CABG with left ventricular dysfunction. Atherosclerosis of coronary artery bypass graft(s), unspecified, with other forms of angina pectoris

Interventions

Intervention 1: Control group: CABG candid patients who suffer from left ventricular dysfunction and received non-pulsatile flow during the surgery via Pump machine. Intervention 2: Intervention grou

Eligibility

Sex/Gender

All

Age

40 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients referring to Operation room for Elective CABG in dependent hospitals to Shiraz University of Medical Sciences participation satisfaction in attending the project left Ventricular dysfunction Bypass Coronary Grafting Surgery enjoying EF pulsatile lower than 40 percent( based on Suggestions from American Cardiography Association) equivalent to severe left ventricular dysfunction Ages from 40 to 75

Exclusion criteria

Exclusion criteria: lack of patient's tendency to continue the study simultaneous surgery of Valve and Coronary Anesthesia risk more than 3 Sepsis Renal dysfunction (Cr>1.5) Redo Liver Dysfunction Records of brain stroke Concurrent autoimmune diseases Records of immunosuppressive drugs, Chemotherapy or radiotherapy emergency patients

Design outcomes

Primary

Measure	Time frame
Renal parameter UO24h. Timepoint: Before bypass surgery, During bypass surgery, three days after bypass surgery,. Method of measurement: Laboratory variables were sent to the laboratory and got analyzed with the related devices. 24-hour urine volume after the surgery was measured by the ICU nurses.;Renal parameter BUN. Timepoint: Before bypass surgery, During bypass surgery, three days after bypass surgery,. Method of measurement: Laboratory variables were sent to the laboratory and got analyzed with the related devices. 24-hour urine volume after the surgery was measured by the ICU nurses.;Renal parameter GFR. Timepoint: Before bypass surgery, During bypass surgery, three days after bypass surgery,. Method of measurement: Laboratory variables were sent to the laboratory and got analyzed with the related devices. 24-hour urine volume after the surgery was measured by the ICU nurses.;Renal parameter Cr. Timepoint: Before bypass surgery, During bypass surgery, three days after bypass surgery,. Method of measurement: Laboratory variables were sent to the laboratory and got analyzed with the related devices. 24-hour urine volume after the surgery was measured by the ICU nurses.	—

Measure

Time frame

Renal parameter UO24h. Timepoint: Before bypass surgery, During bypass surgery, three days after bypass surgery,. Method of measurement: Laboratory variables were sent to the laboratory and got analyzed with the related devices. 24-hour urine volume after the surgery was measured by the ICU nurses.;Renal parameter BUN. Timepoint: Before bypass surgery, During bypass surgery, three days after bypass surgery,. Method of measurement: Laboratory variables were sent to the laboratory and got analyzed with the related devices. 24-hour urine volume after the surgery was measured by the ICU nurses.;Renal parameter GFR. Timepoint: Before bypass surgery, During bypass surgery, three days after bypass surgery,. Method of measurement: Laboratory variables were sent to the laboratory and got analyzed with the related devices. 24-hour urine volume after the surgery was measured by the ICU nurses.;Renal parameter Cr. Timepoint: Before bypass surgery, During bypass surgery, three days after bypass surgery,. Method of measurement: Laboratory variables were sent to the laboratory and got analyzed with the related devices. 24-hour urine volume after the surgery was measured by the ICU nurses.

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Secondary

Measure	Time frame
BMI. Timepoint: Before bypass surgery. Method of measurement: Based on Patient's File.;Bleeding rate. Timepoint: three days after bypass surgery in ICU. Method of measurement: Bleeding rate was determined based on the scaled chest bottle tube.;Gender. Timepoint: Before bypass surgery. Method of measurement: Based on Patient's File.;Age. Timepoint: Before bypass surgery. Method of measurement: Based on Patient's File.;EF. Timepoint: Before bypass surgery. Method of measurement: Based on Patient's File.	—

Measure

Time frame

BMI. Timepoint: Before bypass surgery. Method of measurement: Based on Patient's File.;Bleeding rate. Timepoint: three days after bypass surgery in ICU. Method of measurement: Bleeding rate was determined based on the scaled chest bottle tube.;Gender. Timepoint: Before bypass surgery. Method of measurement: Based on Patient's File.;Age. Timepoint: Before bypass surgery. Method of measurement: Based on Patient's File.;EF. Timepoint: Before bypass surgery. Method of measurement: Based on Patient's File.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Zamani Jahromi

Shiraz University of Medical Sciences

marziehzamani@jums.ac.ir+98 71 5426 7727

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026