Probiotics: A Promising Strategy to Reduce gavage return

Effect of probiotics in reducing gavage return in intensive care unit patients: a randomized clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190215042716N4

Enrollment

Registered

2023-12-09

Start date

2023-12-22

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric regurgitation. Gastro-esophageal reflux disease

Interventions

Intervention group: Probiotic group receiving Lactobacillus casei capsules "This group was randomly selected and will receive probiotic capsules containing Lactobacillus casei for 14 days..

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Adult patients (18 years of age or older) admitted to the intensive care unit (ICU) Patients requiring tube feeding Patients with symptoms of gastroesophageal reflux (GERD), such as vomiting, diarrhea, nausea, etc.

Exclusion criteria

Exclusion criteria: Presence of underlying GI disease Prior antibiotic use Known allergy to probiotic ingredients Pregnancy or lactation Coagulation disorders or thrombocytopenia

Design outcomes

Primary

Measure	Time frame
Incidence and severity of regurgitation, vomiting, and diarrhea". Timepoint: Daily. Method of measurement: measured using 24-hour nursing charting forms.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNavid Shafigh

Shahid Beheshti University of Medical Sciences

n.shafigh@sbmu.ac.ir+98 21 8801 3378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026