Comparison of Dexmedetomidine and Propofol in sedation efficacy in patients with elective upper gastrointestinal endoscopy

A Comparison of Dexmedetomidine and Propofol in sedation efficacy in patients with elective upper gastrointestinal endoscopy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190212042688N1

Enrollment

Registered

2019-03-02

Start date

2019-03-15

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Upper gastrointestinal disorders. Encounter for screening for upper gastrointestinal disorder

Interventions

Intervention 1: Intervention group: Dexmedetomidine - In D group, Dexmedetomidine doses of 0.5µg/kg bolus and 0.7-0.5µg/Kg/hr infusion will given intravenously to patients. Intervention 2: Interventio

Eligibility

Sex/Gender

All

Age

20 Years to 70 Years

Inclusion criteria

Inclusion criteria: patients with elective upper gastrointestinal endoscopy ASA class =3

Exclusion criteria

Exclusion criteria: Having cardiovascular disease (arrhythmia, AS, IHD, HTN, HF or EF <30%) Having liver disease (Child-Pugh Classification C) Having kidney disease (GFR <60%) Having psychiatric illness (Major Depression, Mania, Psychosis) SBP<90 Having Drug Addiction Egg and soy allergy Emergency endoscopy

Design outcomes

Primary

Measure	Time frame
Sedation. Timepoint: By monitoring, sedation will be recorded from the start of the drug administration (time 0) and every 5 minutes until the patient transferred to the recovery room. Method of measurement: Relaxation after taking drugs will asked using Ramsay Relaxation Scale from 0-5 (0-Restless,1-Relax,2-Sleepy,3-Confuse but Responded to Verbal Orders,4-No Response to Verbal orders,5-No Response to painful incitements) and will evaluated by an anesthesiologist.	—

Measure

Time frame

Sedation. Timepoint: By monitoring, sedation will be recorded from the start of the drug administration (time 0) and every 5 minutes until the patient transferred to the recovery room. Method of measurement: Relaxation after taking drugs will asked using Ramsay Relaxation Scale from 0-5 (0-Restless,1-Relax,2-Sleepy,3-Confuse but Responded to Verbal Orders,4-No Response to Verbal orders,5-No Response to painful incitements) and will evaluated by an anesthesiologist.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactParnia Sayarfar

Zahedan University of Medical Sciences

parneia.saiyarfar@gmail.com+98 54 3329 5796

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026