Dry skin.
Conditions
Interventions
Intervention 1: Intervention group: Tpical use of 25 µL of 2 types of super moisturizers: Prime 24 hours moisturizer (containing Imperata Cylindrica as active ingredient) and Euccerin Aquaporin acti
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Male or female aged 18-60 years The presence of skin dryness Voluntary participation and signing written informed consent
Exclusion criteria
Exclusion criteria: Active skin diseases Active smoking Pregnancy or breastfeeding Using systemic corticosteroid in the past 30 days Use of any topical drugs in the past 7 days Scar, wound or any condition on the inner forearms that could interfere with a clear-cut assessment of the skin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison the change in stratum corneum hydration after using two types of moisturizers and cream base formulation. Timepoint: Before intervention and 1 and 4 hours, 24 h, 2weeks after using and one week after not using. Method of measurement: Corneometry. | — |
Secondary
| Measure | Time frame |
|---|---|
| Aquaporin 3 (AQP3) mRNA level. Timepoint: After two weeks application. Method of measurement: Real time PCR.;Trans Epidermal Water Loss. Timepoint: Before intervention and 1 and 4 hours, 24 h, 2weeks after using and one week after not using. Method of measurement: Tewameter.;Skin elasticity. Timepoint: Before intervention and 1 and 4 hours, 24 h, 2weeks after using and one week after not using. Method of measurement: Cutometery. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAniseh Samadi
Tehran University of Medical Sciences
Outcome results
None listed