Evaluation of safety and efficacy profile of the topical 20% vitamin C serum after laser treatment for hyper pigmentation on the face

Evaluation of safety and efficacy profile of the topical 20% vitamin C serum after laser treatment for hyper pigmentation with Q-switched or Pico laser on patients with melasma skin pigmentation on the face

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190210042676N38

Enrollment

Registered

2025-01-08

Start date

2024-12-21

Completion date

Unknown

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperpigmentation. Other melanin hyperpigmentation

Interventions

Intervention 1: Intervention group: After the laser procedure, will receive Lafarrerr serum containing 20% ??vitamin C, made by Fartak Lotus Chemical Industries, containing ascorbic acid, vitamin A an

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: 20 -60 years old men and women Moderate to severe melasma skin spots on the face Signing the informed consent form

Exclusion criteria

Exclusion criteria: History of hormonal skin spots and spots caused by the use of contraceptives History of immune system disorders and autoimmune skin diseases (including psoriasis, lupus, dermatitis, etc.) History of thyroid disorders Pregnancy and lactating

Design outcomes

Primary

Measure	Time frame
Modified melasma severity index. Timepoint: Before intervention and 2 weeks after intervention. Method of measurement: Using mMASI index.	—

Secondary

Measure	Time frame
Size and amount of skin spots. Timepoint: Before intervention and 2 weeks after using. Method of measurement: Visio face device.;Skin melanin content changes. Timepoint: Skin melanin content changes. Method of measurement: Mexameter.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAniseh Samadi

Tehran University of Medical Sciences

aniseh_samadi@yahoo.com+98 21 8896 0880

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026