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Comparison of successful abortion using misoprostol alone and misoprostol with vaginal estrogen

Comparison of successful induced abortion using misoprostol alone and misoprostol with vaginal estrogen in women candidates for first and second trimester abortions

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190208042655N2
Enrollment
120
Registered
2022-03-16
Start date
2022-04-30
Completion date
Unknown
Last updated
2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The first and second trimester abortions. Spontaneous abortion

Interventions

Intervention 1: Intervention group: In women candidates for abortion, misoprostol is prescribed according to FIGO criteria. In addition, half of a vaginal estrogen ointment is administered, an hour be

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Mother age more than 18 years Gestational age up to 28 weeks First gravidity First cesarean section repeat Body mass index between 25 to 35 kg/m2 Hemoglobin level more than 10 gr/dL

Exclusion criteria

Exclusion criteria: Scar in the uterine Leiomyoma in the uterine Blood coagulation disorder Previous attempts to induce abortion in the current pregnancy A medical disorder that prohibits abortion for example heart failure Allergy to misoprostol or estradiol Cervicitis and vaginitis Polyhydramnios The patient withdrawal to participate in the study

Design outcomes

Primary

MeasureTime frame
Successful abortion. Timepoint: Once, at the end of abortion. Method of measurement: Abortion product observation (placenta and fetus residual).

Secondary

MeasureTime frame
Number of doses of misoprostol used. Timepoint: Once, at the end of abortion. Method of measurement: Counting misoprostol doses.;Need to surgery. Timepoint: Once, at the end of abortion. Method of measurement: Curettage or hysterectomy conducting.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNafiseh Saedi

Tehran University of Medical Sciences

nsaedi@sina.tums.ac.ir+98 21 8608 9089

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026