The Comparison of efficacy of Levetiracetam and Carbamazepine in the treatment of Rolandic seizures in children

A comparative study on the efficacy of Levetiracetam and Carbamazepine in the treatment of Rolandic seizures in children referred to the pediatric neurology clinics of Imam Hossein hospital- Isfahan University of Medical Sciences in 2019; An open-label randomized controlled trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190208042654N3

Enrollment

Registered

2020-01-07

Start date

2019-10-12

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rolandic seizure. Epilepsy and recurrent seizures

Interventions

Intervention 1: Intervention group: Levetiracetam group treated with Lovebel syrup (100 mg/ml) with 30 mg/kg/day for 6 months. Intervention 2: Control group: Carbamazepine group treated with Tegertol

Eligibility

Sex/Gender

All

Age

4 Years to 12 Years

Inclusion criteria

Inclusion criteria: Children with BECTS (clinical diagnosis and EEG in favor of Rolandic epilepsy) with more than two attacks per year Medicated with only one drug Age above 4 years under 12 years and Normal MRI

Exclusion criteria

Exclusion criteria: Lack of consent to enter the study Severe side effects and drug reactions to Levetiracetam or Carbamazepine Multi-drug therapy Inability to follow up the patients

Design outcomes

Primary

Measure	Time frame
Frequency, duration, and severity of seizure attacks and drug side effects. Timepoint: before treatment and every two months for 6 months. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJafar Nasiri

Esfahan University of Medical Sciences

Nasiri.jafar@gmail.com+98 31 3386 6266

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026