Drug induced constipation. Constipation
Conditions
Interventions
Intervention 1: Intervention group 1: The blinded therapists of HRCs delivers 7 coded capsules contain 2 mg Naloxan ( Sigma ) after initial evaluation ( for seven days ). The capsuled were filled b
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Participants that are in the opium tincture treatment in the 5 first months. Willingness to participate in research studies. Receiving the average dose of the opium tincture less than 10 CC in the last month. Age between 20 - 50 years.
Exclusion criteria
Exclusion criteria: Past history of GI surgery History of Thyroid disease History of Diabetes Hypercalcemia Renal failure Using Tricyclic antidepressant Using Calcium Chanel blockers Hypertension Cardiac disease Multi-drugs abuser Using anticholinergic drugs Pregnancy Recently sever weight loss more than 4 NVD or past history of severe labor Parkinsonism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Constipation score. Timepoint: At the start of treatment , one and two weeks later (end of research). Method of measurement: CONSTIPATION SCORING SYSTEM and Briston scoring.;Defecation in the three areas of abdominal, rectal and feces. Timepoint: At the start of treatment , one and two weeks later (end of research). Method of measurement: PAC-SYM questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Opiate withdrawal scoring. Timepoint: 24 hours after starting the treatment patients were evaluated by phone call. One and two weeks later ( end of research) were scored. Method of measurement: opiate withdrawal scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Moshiri
Mashhad University of Medical Sciences
Outcome results
None listed