Drug induced constipation. Constipation
Conditions
Interventions
Intervention 1: Intervention group:they will be treated by oral naloxane capsules ( 0.5 or 2 or 4 mg/day) .Also, they will be treated by their previous laxative medication without change. Interven
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Participant in the MMT program for at least three months Willingness to participate in research studies Receive methadone less than 75 mg /day
Exclusion criteria
Exclusion criteria: Past history of GI surgery (Except Appendectomy) History of Thyroid disease History of diabetes mellitus. Hypercalcemia renal failure using Tricyclic antidepressant Using Calcium Chanel blockers Hypertension cardiac disease Multi-drugs abuser Using anticholinergic drugs Pregnancy Recently weight loss More then 4 NVD or Past history of Severe labor Parkinsonism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ??Constipation score. Timepoint: At start, one and two weeks later (end of research). Method of measurement: Constipation Scoring System and Briston scoring.;Defecation in the three areas of abdominal, rectal and feces. Timepoint: At start , one and two weeks later ( end of research). Method of measurement: PAC-SYM questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Constipation scoring. Timepoint: At start , one and two weeks later ( end of research). Method of measurement: PAC-SYM questionnaire and Constipation Scoring System.;Opiate withdrawal scoring. Timepoint: One and two weeks later ( end of research). Method of measurement: opiate withdrawal scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Mohammad Moshiri
Mashhad University of Medical Sciences
Outcome results
None listed