The effect of acetaminophen and pethidine on reducing the pain of the first stage of labor and its complications in primipara women

Comparison of the effectiveness of acetaminophen and pethidine in the first stage of labor on reducing the pain and maternal complications of primigravid women

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190202042595N1

Enrollment

100

Registered

2019-02-13

Start date

2018-12-24

Completion date

Unknown

Last updated

2019-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delivery. Single spontaneous delivery

Interventions

Intervention 1: First Intervention group: Acetaminophen receptor, 100 mg of acetaminophen in 100 cc serum ringer lactate within 15 minutes. Intervention 2: Second Intervention group: Pethidine, 50 mg

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Single with cephalic presentation Pregnant women requesting a reduction in labor pain

Exclusion criteria

Exclusion criteria: Underlying disease(cardiac, hepatic, renal, pulmonary) Preeclampsia Diabetes Drug abuse Sensitization to acetaminophen and opioids G6PD deficiency Cesarean section history

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Before drug administration, 30 minutes, 1, 2, 3 and 4 hours after drug administration. Method of measurement: Visual analog scale(VAS) by graded ruler (0 to 10), which zero is painless and 10 most severe pain states.;Maternal complications. Timepoint: From the time of drug injection to 4 hours after delivery. Method of measurement: Nausea, vomiting, drowsiness, respiratory depression.;Duration of the first stage of labor. Timepoint: Distilation time of 4 cm to complete dilatation. Method of measurement: minute.	—

Measure

Time frame

Pain. Timepoint: Before drug administration, 30 minutes, 1, 2, 3 and 4 hours after drug administration. Method of measurement: Visual analog scale(VAS) by graded ruler (0 to 10), which zero is painless and 10 most severe pain states.;Maternal complications. Timepoint: From the time of drug injection to 4 hours after delivery. Method of measurement: Nausea, vomiting, drowsiness, respiratory depression.;Duration of the first stage of labor. Timepoint: Distilation time of 4 cm to complete dilatation. Method of measurement: minute.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoume Khammar

Rafsanjan University of Medical Sciences

masoume.khammar@rums.ac.ir+98 34 3425 5900

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026