The effect of physical and mental training on mental indicators, irisin and BDNF

Comparison of physical and mental exercises on mental indicators, serum irisin and brain derived neurotrophic factor (BDNF) levels in elderly

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190131042571N1

Enrollment

100

Registered

2020-06-26

Start date

2019-09-11

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Depression. Condition 2: Insomnia. Moderate depressive episode Nonorganic insomnia

Interventions

Intervention 1: Intervention group 1: Group One (MSROM Physical Exercise): These exercises are special for the elderly, and the equipment used includes a chair, a light ball, 2 to 3 pounds, and a resi

Eligibility

Sex/Gender

All

Age

60 Years to 95 Years

Inclusion criteria

Inclusion criteria: A score of 5 to 10 in the GDS-SF questionnaire A score of 15 to 21 in the Insomnia Intensity Index (ISI) Normal or nearly normal visual and hearing abilities Ability to read and write.

Exclusion criteria

Exclusion criteria: any motor, skeletal and physiological disturbances using antidepressant and anti-Alzheimer's medications

Design outcomes

Primary

Measure	Time frame
Score 5 to 10 in the Geriatric Depression Scale Short Form (GDS-SF). Timepoint: The beginning of the study (before the intervention) and the end of the study (after 8 weeks). Method of measurement: Geriatric Depression Scale Short Form (GDS-SF) Questionnaire.;Score 15 to 21 in the Insomnia Severity Index (ISI). Timepoint: The beginning of the study (before the intervention) and the end of the study (after 8 weeks). Method of measurement: Insomnia Severity Index (ISI) Questionnaire.;Irisin. Timepoint: The beginning of the study (before the intervention) and the end of the study (after 8 weeks). Method of measurement: irisin Laboratory Kit.;Brain derived neurotrophic factor (BDNF). Timepoint: The beginning of the study (before the intervention) and the end of the study (after 8 weeks). Method of measurement: BDNF Laboratory Kit.	—

Measure

Time frame

Score 5 to 10 in the Geriatric Depression Scale Short Form (GDS-SF). Timepoint: The beginning of the study (before the intervention) and the end of the study (after 8 weeks). Method of measurement: Geriatric Depression Scale Short Form (GDS-SF) Questionnaire.;Score 15 to 21 in the Insomnia Severity Index (ISI). Timepoint: The beginning of the study (before the intervention) and the end of the study (after 8 weeks). Method of measurement: Insomnia Severity Index (ISI) Questionnaire.;Irisin. Timepoint: The beginning of the study (before the intervention) and the end of the study (after 8 weeks). Method of measurement: irisin Laboratory Kit.;Brain derived neurotrophic factor (BDNF). Timepoint: The beginning of the study (before the intervention) and the end of the study (after 8 weeks). Method of measurement: BDNF Laboratory Kit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Hosseini

Islamic Azad University

f-hosseini@aliabadiau.ac.ir+98 17 3422 4500

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026