Effect of L-Carnitine on QT-Dispersion of patients with acute myocardial infarction in Rafsanjan Ali Ibn-Abitaleb Hospital: A randomized, double-blind, placebo-controlled trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190128042525N3

Enrollment

200

Registered

2020-06-10

Start date

2018-10-23

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with acute myocardial infarction. ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction

Interventions

Intervention 1: Intervention group:60 patients with acute myocardial infarction admitted to Ali Ibn Abi Talib Hospital in Rafsanjan. L-carnitine treatment group. (Oral L-carnitine tablets will be pres

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with Acute Myocardial Infarction with History, Examination, ECG and Cardiac Enzymes and Angiography Patients undergoing angiography have more than 80% coronary stenosis The type and extent of MI and age restriction are not relevant in this study.

Exclusion criteria

Exclusion criteria: Moderate and severe valvular disease Pregnancy Left and right bundle branch block Patients taking vitamin supplements Patients taking QT prolonging drugs (amiodarone, sotalol, quinidine, azithromycin, clarithromycin, erythromycin) Underlying diseases such as diabetes (due to the effect of diabetes-induced oxidative stress on the antioxidant effects of L-carnitine) and liver failure (due to hepatic drug metabolism), and chronic renal failure grade 4 and 5 (GFR <30 mL / min / 1.73)

Design outcomes

Primary

Measure	Time frame
In the study "Effect of oral L-carnitine tablets on QT-dispersion in patients with acute myocardial infarction hospitalized at Ali Ibn Abi Talib Hospital in Rafsanjan" the primary outcome could be "reduced QT-dispersion". Timepoint: In the study "Effect of oral L-carnitine tablets on QT-dispersion in patients with acute myocardial infarction hospitalized in Hazrat Ali Ibn Abi Talib Hospital in Rafsanjan" is the timing of measurement of QT-dispersion in the first day of study and last day. Method of measurement: The Method of measurement: how to measure the outcome variable: QT-dispersion is calculated by measuring the difference between the largest and the smallest QT. Interval in 12-lead of Electrocardiogram.	—

Measure

Time frame

In the study "Effect of oral L-carnitine tablets on QT-dispersion in patients with acute myocardial infarction hospitalized at Ali Ibn Abi Talib Hospital in Rafsanjan" the primary outcome could be "reduced QT-dispersion". Timepoint: In the study "Effect of oral L-carnitine tablets on QT-dispersion in patients with acute myocardial infarction hospitalized in Hazrat Ali Ibn Abi Talib Hospital in Rafsanjan" is the timing of measurement of QT-dispersion in the first day of study and last day. Method of measurement: The Method of measurement: how to measure the outcome variable: QT-dispersion is calculated by measuring the difference between the largest and the smallest QT. Interval in 12-lead of Electrocardiogram.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFateme Askari Hosni

Rafsanjan University of Medical Sciences

clinical.research@rums.ac.ir+98 34 3428 0185

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026