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The impact of prophylactic pantoprazole dosage on the occurrence of marginal ulcer following one anastomosis gastric bypass surgery in patients with severe obesity

The impact of prophylactic pantoprazole dosage on the occurrence of marginal ulcer following one anastomosis gastric bypass surgery in patients with severe obesity

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190128042520N7
Enrollment
120
Registered
2024-05-27
Start date
2024-06-21
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Marginal ulcer. Marginal corneal ulcer

Interventions

Intervention 1: Intervention group 1: Pantoprazole 40 mg every 12 hours. Intervention 2: Intervention group 2: Pantoprazole 20 mg every 12 hours. Intervention 3: Intervention group 3: Pantoprazole 40

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with a Body Mass Index (BMI) of 40 or more Patients aged 18 to 65 years Insensitivity to pantoprazole Patients who underwent primary single anastomotic bypass surgery

Exclusion criteria

Exclusion criteria: Patients who do not want to continue the study and withdraw will be excluded from the study. Patients who are not able to continue the treatment due to special conditions at each stage of the plan. Patients who show sensitivity due to the use of pantoprazole and side effects. Patients who take aspirin, NSAIDs, corticosteroids, blood thinners, or oral anticoagulants. Patients who smoke, hookah and any tobacco. Patients who undergo a change in the prescription dose of pantoprazole due to the complication or the prescription of an antacid drug or H2 blocker at the same time.

Design outcomes

Primary

MeasureTime frame
Marginal ulcer. Timepoint: One year after surgery. Method of measurement: Endoscopy.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Kerman Saravi

Iran University of Medical Sciences

mkermansaravi@yahoo.com+98 21 8871 7272

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026