Persistent pulmonary hypertension of newborn. Persistent pulmonary hypertension
Conditions
Interventions
Intervention 1: Intervention group 1: Newborns with PPHN treated with Bosentan tablet 1mg/kg/dose every 12 hours through PG until 1 mounths. Intervention 2: Intervention group2 : Newborns with PPHN tr
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Days to 30 Days
Inclusion criteria
Inclusion criteria: All new borns with respiratory distress, decreased of Sat o2 and cyanossies admitted to the NICU of Akbarabadi and Ali Asghar hospital If the echocardiography findings are based on pulmonary artery pressure higher than or equal to 25 mmHg The severity of tricuspid valve regurgitation higher than or equal to 30 mmHg with or without right to left shunt Obtaining the consent of the parents
Exclusion criteria
Exclusion criteria: Other cyanotic heart disease No other cyanotic justifying disease PPHN is not due to pneumonia or meconium aspiration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary artery pressure. Timepoint: At the start of study and then 1week after. Method of measurement: Echocardiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of the duration of treatment in the two groups. Timepoint: daily visit. Method of measurement: Physical examination.;Comparison of the duration of O2 as needed in two groups. Timepoint: Daily visit. Method of measurement: Pulseoximetery.;Comparrison of side effect in 2 groups. Timepoint: Daily visit,weekly labratory test. Method of measurement: Blood pressure,labratory. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaba Farhangdoust
Iran University of Medical Sciences
Outcome results
None listed