Letrozole impact on the final height of boys with short stature

The effect of Letrozole on final stature in boys aged 11-16 years old with constitutional short stature or familial short stature

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190123042468N1

Enrollment

100

Registered

2019-05-14

Start date

2019-05-22

Completion date

Unknown

Last updated

2019-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Short stature of children. Short stature (child)

Interventions

Intervention 1: Intervention group: Treatment with letrozole, 2.5 mg/d for one year. Intervention 2: Control group: Placebo treatment.

Eligibility

Sex/Gender

Male

Age

12 Years to 16 Years

Inclusion criteria

Inclusion criteria: Healthy boys 16-12 years old Constitutional short stature or familial short stature Normal physical examination

Exclusion criteria

Exclusion criteria: Systemic disease Malnutrition Hypothyroidism Underlying or genetically disease Treatment with corticosteroids Glands disorders Children who have both constitutional and genetic short stature

Design outcomes

Primary

Measure	Time frame
Growth rate. Timepoint: One year after the start of treatment. Method of measurement: Height difference at start and end of treatment.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Shamsi

Qazvin University of Medical Sciences

m.shamsi@aums.ac.ir+98 28 3336 1733

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026