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The effects of zinc supplementation on reducing polyp recurrence in patients with chronic rhinosinusitis

Comparing the effects of zinc supplementation on reducing polyp recurrence in patients with chronic rhinosinusitis and inflammatory and allergic nasal polyps referred to Taleghani Hospital

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190122042460N1
Enrollment
40
Registered
2025-05-18
Start date
2025-05-31
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polyp. Nasal polyp

Interventions

Intervention 1: Intervention group: Postoperatively, patients in the first group will receive a 1-month course of oral prednisolone at a dose of 0.5 mg/kg of body weight. This will be followed by a 3-

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Without underlying diseases including cystic fibrosis, Kartagener syndrome, Wegener's vasculitis, vasculitides, sarcoidosis, and rheumatologic diseases. They should not have taken zinc as a dietary supplement in the past 3 months. The patients included in the study must not have received systemic corticosteroid therapy or undergone previous sinus surgery.

Exclusion criteria

Exclusion criteria: No postoperative follow-up. Any histopathological diagnosis other than sinonasal polyposis (SNP), such as malignancies. No postoperative medication use.

Design outcomes

Primary

MeasureTime frame
Polyp recurrence. Timepoint: Before the intervention, and at 1, 3, and 6 months after the intervention. Method of measurement: Clinical examination and Sino-nasal Outcome Test (SNOT-22) questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMatin Ghazizadeh

Shahid Beheshti University of Medical Sciences

matinghazizadeh@sbmu.ac.ir+98 21 2303 1317

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026