Condition 1: Digestive System Surgical Procedures. Condition 2: selenium deficiency. Condition 3: Congenital diaphragmatic hernia. Condition 4: Acute abdomen. Condition 5: Congenital malformations of esophagus. Condition 6: Other specified congenital malformations of upper alimentary tract. Condition 7: Congenital disorders of small intestine. Condition 8: Congenital disorders of large intestine. Condition 9: Congenital malformations of gallbladder, bile ducts and liver. Unspecified intestinal
Conditions
Interventions
Intervention 1: Intervention group: Selenium supplementation will continue to be given at a dose of 20 µg / kg / d for 10 days or until discharge from the intensive care unit or death. High-dose selen
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Days to 10 Years
Inclusion criteria
Inclusion criteria: 0-10 years old patients undergoing major gastrointestinal surgery at the Akbar Hospital of Mashhad Admission to the intensive care unit due to medical indications Filling out the informed consent form by a parent or legal guardian Stability of hemodynamic and metabolic status in the first 24 to 48 hours
Exclusion criteria
Exclusion criteria: Patients who are not allowed to start a nutrition support care for them within the first 24-48 hours Diagnosed autoimmune disorders Diagnosed cancers Severe sepsis at the admission time History of chemotherapy and radiotherapy in the past month Diagnosed renal failure Diagnosed severe hepatic failure Severe and active bleeding A known case of human immunodeficiency virus Preterm neonates
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pro-oxidant- Antioxidant Balance (PAB) status. Timepoint: before intervention and after 10 days. Method of measurement: Pro-oxidant- Antioxidant Balance (PAB) assay.;Inflammatory factors. Timepoint: before intervention and after 10 days. Method of measurement: Interleukin 1 beta: ELISA, high-sensitivity C-reactive protein (hs-CRP) test: Immunoturbidimetry. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum and urine selenium Level. Timepoint: before intervention and 1, 10 days after intervention. Method of measurement: atomic absorpsion.;Serum Glutathione peroxidase level. Timepoint: before intervention and 1, 10 days after intervention. Method of measurement: ELISA. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Roudi
Mashhad University of Medical Sciences
Outcome results
None listed