Skip to content

Investigating the effect of dexmedetomidine and propofol on hemodynamic and laboratory parameters of patients with secondary hyperparathyroidism caused by uremia

Comparison of the effect of dexmedetomidine and propofol on laboratory parameters of patients with secondary hyperparathyroidism caused by uremia in parathyroidectomy surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190121042444N6
Enrollment
60
Registered
2024-09-04
Start date
2024-08-10
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Secondary hyperparathyroidism. Secondary hyperparathyroidism of renal origin

Interventions

Intervention 1: Intervention group: In this group, dexmedetomidine as a bolus of 0.5 to 1 µg/kg for 10 minutes before induction and then infusion of 0.3 to 0.5 µg/kg per hour with 5/ isoflurane gas. M

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Ages 18 to 80 years ASA class 2 who is a candidate for parathyroidectomy surgery Secondary hyperparathyroidism Elective surgery

Exclusion criteria

Exclusion criteria: Primary or tertiary hyperparathyroidism History of previous thyroid surgery Operation performed by any other surgeon Incomplete anesthesia or surgery records ASA class 1 and 3 and above Emergency surgery

Design outcomes

Primary

MeasureTime frame
Blood pressure. Timepoint: Before the intervention, 15 minutes during the operation and 30 minutes after the operation. Method of measurement: Automatic pressure gauge.;Heart rate. Timepoint: Before the intervention, 15 minutes during the operation and 30 minutes after the operation. Method of measurement: Monitoring.;Oxygen saturation percentage. Timepoint: Before the intervention, 15 minutes during the operation and 30 minutes after the operation. Method of measurement: Monitoring.;Urea. Timepoint: Before the intervention and one hour after the operation. Method of measurement: Measurement of serum levels in a blood test.;Creatinine. Timepoint: Before the intervention and one hour after the operation. Method of measurement: Measurement of serum levels in a blood test.;ESR. Timepoint: Before the intervention and one hour after the operation. Method of measurement: Percentage measurement in blood test.;Calcium. Timepoint: Before the intervention and one hour after the operation. Method of measurement: Measurement of serum levels in a blood test.;Phosphorus. Timepoint: Before the intervention and one hour after the operation. Method of measurement: Measurement of serum levels in a blood test.;Parathormone hormone. Timepoint: Before the intervention and one hour after the operation. Method of measurement: Measurement of serum levels in a blood test.;Bispectral Index. Timepoint: Before the intervention, 15 minutes during the operation and 30 minutes after the operation. Method of measurement: monitoring.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFaranak Behnaz

Shahid Beheshti University of Medical Sciences

faranak.behnaz@gmail.com+98 21 2274 1174

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026