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"Investigation of the effect of anesthetic propofol on gene expression"; "Investigation of the effect of the anesthetic Isoflurane on gene expression"

Comparison of the effects of two drugs, propofol and isoflurane, as anesthetic agents on gene expression mt-DNA in posterior vertebral fixation surgeries

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190121042444N5
Enrollment
34
Registered
2024-02-11
Start date
2023-12-12
Completion date
Unknown
Last updated
2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lumbar spine injury. Injuries to the abdomen, lower back, lumbar spine and pelvis(S30-S39)

Interventions

Intervention 1: Intervention group: In order to induce anesthesia in all patients, midazolam 0.01 mg/kg, fentanyl 2 kg/mµ, lidocaine 1.5 mg/kg, propofol 2.5-2 mg/kg, and cis-etracurium 0.2 mg/kg will

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients who are candidates for elective surgery for posterior stabilization of the lumbar spine ASA class I-II

Exclusion criteria

Exclusion criteria: Previous history of surgery ASA class III or higher Malignancies Cardiovascular diseases Chronic inflammatory diseases Corticosteroid use Emergency surgery Any instability of the patient during surgery Drug addiction

Design outcomes

Primary

MeasureTime frame
Level of mt-DNA. Timepoint: before the intervention and 1 hour after the operation and 1 day after the operation. Method of measurement: Measurement of serum levels in a blood test.;Duration of surgery. Timepoint: Surgery start time - surgery end time. Method of measurement: minutes.;Bleeding volume. Timepoint: End of surgery. Method of measurement: milliliter.;Complications of surgery. Timepoint: First of surgery- End of surgery. Method of measurement: Filling out the questionnaire.;Demographic information. Timepoint: The beginning of surgery. Method of measurement: Filling out the questionnaire based on the birth certificate information.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFaranak Behnaz

Shahid Beheshti University of Medical Sciences

faranak.behnaz@gmail.com009821227741174

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026