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Evaluation the effectiveness of rivastigmine and memantine in improving cognitive problems due to electroconvulsive therapy

Comparison of the effectiveness of rivastigmine and memantine in improving cognitive problems due to electroconvulsive therapy

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190119042417N2
Enrollment
45
Registered
2022-06-01
Start date
2022-06-05
Completion date
Unknown
Last updated
2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Psychiatric disorders with electroconvulsive therapy (ECT) indication.

Interventions

Intervention 1: Intervention group 1: The day before receiving ECT and after the Montreal cognitive test, rivastigmine is started at a dose of 1.5 mg in 24 hours and increases to 3 mg (2 capsules) in

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Being in the age range of 18-60 years. Being a candidate to receive electroconvulsive therapy. Collaborate to perform Montreal cognitive assessment. Having informed consent to participate in the study.

Exclusion criteria

Exclusion criteria: History of neurocognitive disorders such as delirium and dementia History of cardiac conductive disorder and arrhythmia History of hepatic, renal, thyroid, and seizure disorders History of sensitivity to rivastigmine and memantine History of electroconvulsive therapy within the the past 6 months Taking calcium channel blockers and cox-inhibitors

Design outcomes

Primary

MeasureTime frame
Cognitive impairment. Timepoint: One day before starting ECT, 2 and 6 weeks after starting ECT. Method of measurement: Montreal Cognitive Scale (MOCA).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParniyan Molaee

Shahid Beheshti University of Medical Sciences

parnianmolaee@yahoo.com+98 21 7755 1023

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026