Polycystic Ovarian Syndrome. Polycystic ovarian syndrome
Conditions
Interventions
Intervention 1: Intervention group: 5 mg of medroxyprogesterone (aburaihan pharmaceutical company) orally daily from day 16 of the cycle for 12 days (up to 2 months) and 1.5 g of bee pollen tablets (t
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: A history of normal puberty have a normal thyroid test meet Retrodam criteria for the diagnosis of polycystic ovary syndrome
Exclusion criteria
Exclusion criteria: Cushing's syndrome hyperprolactinemia hypergonadotropic hypogonadism premature ovarian failure congenital adrenal hyperplasia physical illnesses ovarian and adrenal neoplasms pregnancy history of ovarian surgery in the past 3 months history of previous treatment for polycystic ovary syndrome use of sex steroids (such as birth control pills, hormone therapy, androgen drugs use of chemical or herbal medicines to treat polycystic ovary syndrome use of cigarettes or hookah hypertension (blood pressure higher than 140/90 mm Hg) advanced liver, heart, and kidney disease severe anxiety (score 54 and more based on the Spielberger questionnaire)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spontaneous ovulation. Timepoint: before intervention and days 12 - 14 of Menstrual cycle. Method of measurement: Based on vaginal ultrasound in serial ultrasounds.;Level of testosterones hormone. Timepoint: before intervention and two months after the start of the intervention. Method of measurement: radioimmunoassay.;Blood cholesterol. Timepoint: before intervention and two months after the start of the intervention. Method of measurement: laboratory kit and based on the cholesterol oxidase-peroxidase method.;Fasting blood sugar. Timepoint: before intervention and two months after the start of the intervention. Method of measurement: laboratory kit and based on the glucose oxidase-peroxidase method.;Blood triglycerides. Timepoint: before intervention and two months after the start of the intervention. Method of measurement: laboratory kit and based on the glycerol phosphate oxidase-peroxidase method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hirsutism. Timepoint: before intervention and two months after the start of the intervention. Method of measurement: Freeman-Galway scoring system.;Acne. Timepoint: before intervention and two months after the start of the intervention. Method of measurement: self report of patient.;Occurrence of menstruation. Timepoint: before intervention and two months after the start of the intervention. Method of measurement: self report of patient.;Body mass index. Timepoint: before intervention and two months after the start of the intervention. Method of measurement: meter and weighing machine. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaliheh Afiat
Mashhad University of Medical Sciences
Outcome results
None listed