Low-Risk Nonmetastatic Gestational Trophoblastic Neoplasia. Malignant neoplasms of female genital organs
Conditions
Interventions
Intervention group: Patients with Low-Risk Nonmetastatic Gestational Trophoblastic Neoplasia will undergo a second uterine curettage by a Gynecologist- Oncologist..
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Participants had either a complete or partial mole at their first curettage Women with Low-Risk Nonmetastatic Gestational Trophoblastic Neoplasia Normal Chest X-ray Patients with an initial registration hCG level >20 mIU/mL (in order to minimize inclusion of patients with false-positive hCG tests from circulating heterophilic antibody) Patients without history of chemotherapy
Exclusion criteria
Exclusion criteria: Patients with a first curettage diagnosis of choriocarcinoma, placental-site trophoblastic tumor or epithelioid trophoblastic tumor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the efficacy of second uterine curettage in patients with low-risk, nonmetastatic gestational trophoblastic neoplasia (GTN). Timepoint: After and 6 months after the surgery. Method of measurement: Quantitative B-hCG assay and sonography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events of the second curettage ( Bleeding, Asherman syndrome, uterine rupture and uterine injury ). Timepoint: After and 6 months after the surgery. Method of measurement: Observation and questionnaire, CBC, Sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSoheila Aminimoghaddam
Iran University of Medical Sciences
Outcome results
None listed