Effects of mixture of Distillated of Chicory and Fumitory on hot flash

Effects of mixture of Distillated of Chicory and Fumitory compared with Venlafaxin on hot flashes in women with breast cancer

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190107042275N1

Enrollment

Registered

2019-10-24

Start date

2019-11-01

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer. Malignant neoplasm of breast

Interventions

Intervention 1: Intervention group1: Mixture of distillated of Chicory and Fumitory, obtained by steam distillation of chicory and fumitory leaves at Institute of Medicinal Plants of Shahid Beheshti U

Eligibility

Sex/Gender

Female

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Women between 18 and 65 years Breast cancer (stage 0-3) Having at least two hot flashes in 24 hours At least 4 weeks have elapsed since treatment with estrogen suppressive hormone therapy (Tamoxifen, LHRH agonists, Aromatase inhibitors) and continued unchanged until the end of the intervention.

Exclusion criteria

Exclusion criteria: Lack of informed consent to the plan Life expectancy is less than 6 months Having another cancer at the same time as breast cancer The patient is undergoing chemotherapy, radiotherapy or surgery Use of acupuncture and complementary medicine (hypnosis, psychotherapy) Taking antidepressants in the last 4 weeks Use of Anxiolytic drug, Gabapentin, Pregablin, Clonidine, Aspirin, Vitamin E, Omega 3, Phytoestrogenic supplements and high phytoestrogenic diet Drug allergy to venlafaxine Allergy to distillated of Chicory and Fumitory kidney test (BUN,CR) is not in normal laboratory range Liver enzymes AST and ALT are more than twice the normal laboratory range and Total Billirubin =2

Design outcomes

Primary

Measure	Time frame
Number of hot flashes: average of frequency during a week according to based on Daily Hot flashes Diary. Timepoint: Daily. Method of measurement: Daily Hot flashes ?Diary which is filled daily by the patient.;Severity of hot flashes: average of severity during a week according to based on Daily Hot flashes Diary. Timepoint: Daily. Method of measurement: Each hot flashes is recorded by the patient on a daily hot flashes diary record at 4 degrees of mild, moderate, severe, and very severe.	—

Measure

Time frame

Number of hot flashes: average of frequency during a week according to based on Daily Hot flashes Diary. Timepoint: Daily. Method of measurement: Daily Hot flashes ?Diary which is filled daily by the patient.;Severity of hot flashes: average of severity during a week according to based on Daily Hot flashes Diary. Timepoint: Daily. Method of measurement: Each hot flashes is recorded by the patient on a daily hot flashes diary record at 4 degrees of mild, moderate, severe, and very severe.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSina Moghtadaei

Shahid Beheshti University of Medical Sciences

Sinamoghtadaei@sbmu.ac.ir+98 21 8877 3522

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026