Migraine Headaches. Migraine
Conditions
Interventions
Intervention 1: Intervention group: In both groups of patients, propranolol 20 mg twice a day is used as a standard anti-migraine treatment. In the Intervention group, 3 mg melatonin tablets (Razak co
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Confirmation of migraine according to the criteria of the International Headache Society Chronic migraine patients who are able to distinguish migraine from non-migraine headaches Patients who do not have primary internal and neurologic complaints, there is no other reason for headache in them Filling the written consent form to participate in the study at least 1 year of migraine history
Exclusion criteria
Exclusion criteria: Severe and debilitating migraine (to eliminate the therapeutic effects of excessive use of painkillers) Chronic daily headache Taking drugs other than propranolol to prevent attacks or taking sleeping pills Migraine Disability Assessment (MIDAS) Grade 4 Treatment-resistant migraine (history of unsuccessful treatment with two or more migraine drug classes) History of abnormal use of painkillers and Medication Overuse Headache Significant psychological disorders (psychological illnesses leading to chronic drug use for at least six months) Pregnancy and breastfeeding Primary medical conditions and surgeries that require medical interventions (including contraindications to beta-blockers) Presence of multiple chronic headaches other than migraine with or without medical treatment, such as tension headache History of melatonin allergy or adverse events Patient's request to withdraw from the study due to drug side effects or other reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity. Timepoint: 1, 2, 3 and 4 months after start of treatment. Method of measurement: Visual Analog Scale.;Frequency. Timepoint: 1, 2, 3 and 4 months after start of treatment. Method of measurement: Headache Diary. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAsieh Mehramiri
Ahvaz University of Medical Sciences
Outcome results
None listed