Comparison of Ropivacaine against Ropivacaine and Dexmedetomidine on postoperative pain

Comparison of ultrasound guided intercostal nerve block with ropivacaine against Ropivacaine and Dexmedetomidine on reduction of postoperative pain in patients undergoing thoracotomy: a randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190107042264N2

Enrollment

Registered

2020-11-27

Start date

2020-10-22

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Thoracotomy Pain. Acute post-thoracotomy pain

Interventions

Intervention 1: Intervention group: At the end of the thoracotomy operation, after extubation in recovery and after hemodynamic stability, Intercostal nerve block under ultrasound guidance (model: M7

made by Molteni Farmaceutici, Italy) plus dexmedetomidine 0.5 mcg per kilogram body weight (Medonex, Exir Pharmaceutical Co., Iran) is used, Divided between the three spaces. Intervention 2: Control g

made by Molteni Farmaceutici, Italy), is used, Divided between the three spaces.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists physical status Class I, II or III Body Mass Index less than 40 No History of Alcohol or Drug abuse Not pregnant/Breastfeeding No history of coagulation problems or use of anticoagulants Ejection Fraction more than 30% No history of cardiac conduction block (except for first-degree cardiac block and controlled atrial fibrillation) No acute or chronic hepatitis No history of psychiatric illness No Need for renal supplementation or a history of kidney failure No Known Neuropathy

Exclusion criteria

Exclusion criteria: Hypersensitivity to study drugs

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Immediately after return to Surgical Intensive Care Unit (ICU) from post surgical recovery, then again after 6, 12, 24 and 48 hours from return to surgical ICU. Method of measurement: Visual Analog Scale.	—

Secondary

Measure	Time frame
Systolic Blood Pressure. Timepoint: Immediately after return to Surgical Intensive Care Unit (ICU) from post surgical recovery, then again after 6, 12, 24 and 48 hours from return to surgical ICU. Method of measurement: Aneroid Sphygmomanometer.;Pulse Rate. Timepoint: Immediately after return to Surgical Intensive Care Unit (ICU) from post surgical recovery, then again after 6, 12, 24 and 48 hours from return to surgical ICU. Method of measurement: Pulse Oxymeter.;Oxygen Saturation. Timepoint: Immediately after return to Surgical Intensive Care Unit (ICU) from post surgical recovery, then again after 6, 12, 24 and 48 hours from return to surgical ICU. Method of measurement: Pulse Oxymeter.;Diastolic Blood Pressure. Timepoint: Immediately after return to Surgical Intensive Care Unit (ICU) from post surgical recovery, then again after 6, 12, 24 and 48 hours from return to surgical ICU. Method of measurement: Aneroid Sphygmomanometer.	—

Measure

Time frame

Systolic Blood Pressure. Timepoint: Immediately after return to Surgical Intensive Care Unit (ICU) from post surgical recovery, then again after 6, 12, 24 and 48 hours from return to surgical ICU. Method of measurement: Aneroid Sphygmomanometer.;Pulse Rate. Timepoint: Immediately after return to Surgical Intensive Care Unit (ICU) from post surgical recovery, then again after 6, 12, 24 and 48 hours from return to surgical ICU. Method of measurement: Pulse Oxymeter.;Oxygen Saturation. Timepoint: Immediately after return to Surgical Intensive Care Unit (ICU) from post surgical recovery, then again after 6, 12, 24 and 48 hours from return to surgical ICU. Method of measurement: Pulse Oxymeter.;Diastolic Blood Pressure. Timepoint: Immediately after return to Surgical Intensive Care Unit (ICU) from post surgical recovery, then again after 6, 12, 24 and 48 hours from return to surgical ICU. Method of measurement: Aneroid Sphygmomanometer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactKamran Mahmoudi

Ahvaz University of Medical Sciences

mahmoudi-k@ajums.ac.ir+98 61 3222 2114

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026