Effect of prophylactic administration of magnesium sulfate on cardiovascular changes during general anesthesia in Gynecologic laparoscopic surgery

Effect of prophylactic administration of two doses of magnesium sulfate on cardiovascular changes during general anesthesia in Gynecologic laparoscopic surgery compared with women in the placebo group attending

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190105042236N1

Enrollment

100

Registered

2019-02-10

Start date

2016-10-22

Completion date

Unknown

Last updated

2019-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Effect of prophylactic administration of two doses of magnesium sulfate on cardiovascular changes during general anesthesia in Gynecologic laparoscopic surgery. Magnesium deficiency

Interventions

Intervention 1: Intervention group: Magnesium sulfate at a dose of 30 mg / kg. Intervention 2: Intervention group: Magnesium sulfate at a dose of 50 mg / kg. Intervention 3: Control group: Without get

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patients ASA 1 Patients ASA 2 Women Laparoscopic Surgery Outer uterus and endometriosis and diagnosis (infertility) Maximum operating time is 150 minutes

Exclusion criteria

Exclusion criteria: High blood pressure Sensitization to magnesium sulfate Heart block Emergency situation

Design outcomes

Primary

Measure	Time frame
Change of systolic blood pressure. Timepoint: before the induction of anesthesia as a base and after the anesthesia were measured and recorded after the finishing of the infused medication. These parameters were measured and recorded immediately before the pneumoperitoneum and 5, 10, 20, 30,40 minutes After pneumoperitoneum. Method of measurement: Barometer.;Change of heart rate. Timepoint: before the induction of anesthesia as a base and after the anesthesia were measured and recorded after the finishing of the infused medication. These parameters were measured and recorded immediately before the pneumoperitoneum and 5, 10, 20, 30,40 minutes After pneumoperitoneum. Method of measurement: Pulse oximeter.	—

Measure

Time frame

Change of systolic blood pressure. Timepoint: before the induction of anesthesia as a base and after the anesthesia were measured and recorded after the finishing of the infused medication. These parameters were measured and recorded immediately before the pneumoperitoneum and 5, 10, 20, 30,40 minutes After pneumoperitoneum. Method of measurement: Barometer.;Change of heart rate. Timepoint: before the induction of anesthesia as a base and after the anesthesia were measured and recorded after the finishing of the infused medication. These parameters were measured and recorded immediately before the pneumoperitoneum and 5, 10, 20, 30,40 minutes After pneumoperitoneum. Method of measurement: Pulse oximeter.

—

Secondary

Measure	Time frame
The amount of chills and vomiting. Timepoint: After the recovery. Method of measurement: Objective observation and question.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMona Mostashfi

Esfahan University of Medical Sciences

amirmostashfi@gmail.com+98 31 3267 9440

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026