Unhealed skin ulcers in patients with chronic GVHD skin complications. Chronic graft-versus-host disease
Conditions
Interventions
Intervention 1: Intervention group: Platelet gel from allogeneic cord blood. Cord blood is taken from the umbilical cord blood bank of Bon Yakhte Royan Co. and then in the clean room of the Pediatric
Sponsors
Royan Stem cell Technology Co.
Eligibility
Sex/Gender
All
Age
1 Years to 15 Years
Inclusion criteria
Inclusion criteria: Existence of chronic GvHD criteria after allogeneic hematopoietic stem cell transplantation Wounds in the upper, lower and trunk Wound surface area more than 2 cm2 and less than 5 cm2 with at least 6 weeks durability Wound grading is 2 and 3. Minimum age one year and maximum 15 years
Exclusion criteria
Exclusion criteria: Other diseases such as diabetes, allergies, coagulopathies or underlying diseases that involve the skin Wounds are small (less than 1 cm) or very large (more than 5 cm) Wound grade is 1 or 4. Lesions on the face and neck
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduce wound surface area. Timepoint: At the beginning of the study and 7, 15 and 30 days after the start. Method of measurement: Direct view.;Causes severe allergic reactions. Timepoint: 1, 3 and 7 days after the intervention. Method of measurement: Direct view.;Infection. Timepoint: One week after intervention. Method of measurement: Sampling.;Reduced pain. Timepoint: One month after intervention. Method of measurement: direct examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Normal physical activity. Timepoint: 6 month after intervention. Method of measurement: Direct examination and observation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Rashin Mohseni
Tehran University of Medical Sciences
Outcome results
None listed