The Effect of Allopurinol on Percutaneous Coronary Intervention Outcomes in ST-segment Elevation Myocardial Infarction Patients

The Effect of High dose of Allopurinol loading on Percutaneous Coronary Intervention Outcomes and In-hospital Clinical Results in ST-segment Elevation Myocardial Infarction Patients; A Double-blind Randomized Clinical Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181228042155N1

Enrollment

Registered

2019-07-13

Start date

2019-06-22

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Precancerous Coronary Intervention Outcome. ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction

Interventions

Intervention 1: Intervention group: Received 600 mg Allopurinol loading before precancerous coronary intervention followed by 100 mg daily up to admission, Jalinous pharmaceutical Co. Intervention 2:

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Acute ST-segment elevation MI Symptom onset below 24 hours PCI as primary or rescue approach

Exclusion criteria

Exclusion criteria: Acute STEMI onset more than 24 hours Candide for routine PCI Previous consumption pf Allopurinol and other anti-inflammatory medications Cardiac shock Pulmonary edema with NYHA class 3/4 Mechanical complications of acute STEMI Electrical complication of acute STEMI

Design outcomes

Primary

Measure	Time frame
Coronary flow according to Thrombolysis In Myocardial Infarction (TIMI flow). Timepoint: After precancerous coronary intervention. Method of measurement: Angioplasty videos interpretation.;Coronary flow according to Myocardial blush grade (MBG). Timepoint: After precancerous coronary intervention. Method of measurement: Angioplasty videos interpretation.	—

Secondary

Measure	Time frame
Post MI Electrical and Mechanical complication. Timepoint: During hospitalization. Method of measurement: Electrocardiography and Echocardiography.;Major Adverse Cardiac Events (MACE). Timepoint: During hospitalization. Method of measurement: Questionnaire and physician interpretation.;Troponin level. Timepoint: Admission time and 48 hour after it. Method of measurement: Laboratory kit.;ECG changes. Timepoint: Admission time and after precancerous coronary intervention. Method of measurement: Objective interpretation.	—

Measure

Time frame

Post MI Electrical and Mechanical complication. Timepoint: During hospitalization. Method of measurement: Electrocardiography and Echocardiography.;Major Adverse Cardiac Events (MACE). Timepoint: During hospitalization. Method of measurement: Questionnaire and physician interpretation.;Troponin level. Timepoint: Admission time and 48 hour after it. Method of measurement: Laboratory kit.;ECG changes. Timepoint: Admission time and after precancerous coronary intervention. Method of measurement: Objective interpretation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Kermani-Alghoraishi

Esfahan University of Medical Sciences

sm.kermani@med.mui.ac.ir+98 31 3260 0961

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026