Evaluation of the effect of intracanal medicaments against root canal bacteria of infected primary molar tooth

Antimicrobial Effect of intracanal medicaments(Triple Antibiotic Paste and Calcium hydroxide) Against E.Faecalis Bacteria in infected primary molars by Real-Time PCR :A Randomized Clinical Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181226042132N1

Enrollment

Registered

2019-05-05

Start date

2018-12-22

Completion date

Unknown

Last updated

2019-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infection of primary molars. Necrosis of pulp

Interventions

Intervention 1: Intervention group1:triple antibiotic paste containig minocycline ,ciprofloxacin and metronidazole,once between sessions for 7 days in the root canal system. Intervention 2: Intervent

rinsing with normal saline and using a piece of cotton pellet in pulp chamber between treatment sessions.

Eligibility

Sex/Gender

All

Age

4 Years to 6 Years

Inclusion criteria

Inclusion criteria: Children with infected primary molars tooth with periapical radiolucent lesion

Exclusion criteria

Exclusion criteria: Children should not recieve any antibiotic since 1 month before the treatment session.

Design outcomes

Primary

Measure	Time frame
Changes in Bacteria count in the root canals of infected teeth. Timepoint: Bacteria count at the beginning and 7 days after each two type of intervention. Method of measurement: Polymerase Chain Reaction.;Success rate of treatment after applying each intracanal medicament. Timepoint: recording the clinical status(pain,mobility,swelling,..)and radigraphy(extension of the radiolucent lesion,bone resorption,...)at the begining before the intervention and then two months after the treatment. Method of measurement: examination and record of pain history,mobility grade(1,2,3), examination of swelling status,bone density measurement from radiography.	—

Measure

Time frame

Changes in Bacteria count in the root canals of infected teeth. Timepoint: Bacteria count at the beginning and 7 days after each two type of intervention. Method of measurement: Polymerase Chain Reaction.;Success rate of treatment after applying each intracanal medicament. Timepoint: recording the clinical status(pain,mobility,swelling,..)and radigraphy(extension of the radiolucent lesion,bone resorption,...)at the begining before the intervention and then two months after the treatment. Method of measurement: examination and record of pain history,mobility grade(1,2,3), examination of swelling status,bone density measurement from radiography.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDordaneh Ghaffaripour

Shiraz University of Medical Sciences

dghaffaripour@yahoo.com+98 71 3626 3194

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026