Desensitization to wheat

Desensitization to wheat and relationship of tolerance in patients with T regulatory and specific IgE levels

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181220042066N1

Enrollment

Registered

2020-09-22

Start date

2016-08-22

Completion date

Unknown

Last updated

2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Wheat Allergy, Anaphylaxis, Food Allergy. Anaphylactic reaction due to food

Interventions

Intervention group : Patients with anaphylactic reactions to wheat underwent with Rush Method. Patients underwent the premedication with Cetirizine and Montelukast for three days. Then, they were admi

Eligibility

Sex/Gender

All

Age

5 Years to No maximum

Inclusion criteria

Inclusion criteria: Age more than 5 years A positive history of severe wheat allergy (Anaphylaxis) A positive specific IgE to wheat (in vivo or in vitro tests) Confirmation of wheat allergy by a oral food challenge (OFC)

Exclusion criteria

Exclusion criteria: Dissatisfaction of patients or their parents to perform OFC Viral or bacterial infectious diseases Unstable or uncontrolled asthma in the time of OFC Use of medications in the time of skin prick test (SPT) or DBPCFC

Design outcomes

Primary

Measure	Time frame
1- Evaluation of desensitization to wheat. Timepoint: Evaluation of desensitization to wheat after 12 months after Immunotherapy. Method of measurement: 1- Skin Prick Test,2- Specific IgE measurement, 3-clinical symptoms and oral food challenge.;2-Evaluation of tolerance to wheat. Timepoint: Evaluation of tolerance to wheat after use of free wheat products for two weeks. Method of measurement: clinical symptoms and oral food challenge.	—

Measure

Time frame

1- Evaluation of desensitization to wheat. Timepoint: Evaluation of desensitization to wheat after 12 months after Immunotherapy. Method of measurement: 1- Skin Prick Test,2- Specific IgE measurement, 3-clinical symptoms and oral food challenge.;2-Evaluation of tolerance to wheat. Timepoint: Evaluation of tolerance to wheat after use of free wheat products for two weeks. Method of measurement: clinical symptoms and oral food challenge.

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Secondary

Measure	Time frame
Percentage of T regulatory cells. Timepoint: Before and after Immunotherapy. Method of measurement: Flowcytometry.;Wheal and flare in Skin Prick Test. Timepoint: Before and after Immunotherapy. Method of measurement: observation of wheal and flare.;Specific IgE level to wheat. Timepoint: Before and after Immunotherapy. Method of measurement: Immunoblotting test Allergy screen.;Complications. Timepoint: Before and after Immunotherapy. Method of measurement: examination and observation of clinical symptoms.	—

Measure

Time frame

Percentage of T regulatory cells. Timepoint: Before and after Immunotherapy. Method of measurement: Flowcytometry.;Wheal and flare in Skin Prick Test. Timepoint: Before and after Immunotherapy. Method of measurement: observation of wheal and flare.;Specific IgE level to wheat. Timepoint: Before and after Immunotherapy. Method of measurement: Immunoblotting test Allergy screen.;Complications. Timepoint: Before and after Immunotherapy. Method of measurement: examination and observation of clinical symptoms.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamin Sharafian

Tehran University of Medical Sciences

samin.sh2020@yahoo.com+98 21 6693 3926

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 12, 2026