Effect of non-narcotic agents on postoperative analgesia

Comparative study of effect of second dose of pregabalin, acetaminophen, naproxen and dextromethorphan on postoperative analgesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181219042046N1

Enrollment

Registered

2019-04-19

Start date

2019-04-21

Completion date

Unknown

Last updated

2019-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain. Poisoning by, adverse effect of and underdosing of opium

Interventions

Intervention 1: Intervention group: Administration of the second dose of the combination of Cap Pregabalin 300mg, Tab Acetaminophen 1g, Tab Naproxen 500mg and Tab Dextromethorphan 30 mg for postoperat

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: All patients with ASA-PS score of one to three who are on the list of surgeries: Nephrectomy, Cystetomy, Prostatectomy, Colectomy, Vippel and RPLND and aged 18 to 80 years

Exclusion criteria

Exclusion criteria: Drug addicts Any contraindication and allergy to Pregabalin, Acetaminophen, Naproxen and Dextromethorphan Patients who are not extubated after surgery

Design outcomes

Primary

Measure	Time frame
Pain severity by using UPAT (universal pain assessment tool). Timepoint: Pain measurement at 0, 2, 4, 6, 8, 12, 24, 48 hours after surgery. Method of measurement: UPAT (universal pain assessment tool).	—

Secondary

Measure	Time frame
29/5000Type of pain: somatic or neuropathic. Timepoint: Evaluation at times 0, 2, 4, 6, 8, 12, 24 and 48 hours after surgery. Method of measurement: Descriptive history of the patient.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMajid Amini

Tehran University of Medical Sciences

aminimajid1990@gmail.com+98 31 3441 5047

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026