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The Comparsion between Therapeutic Effects of Intra-articular Botulinum Neurotoxin , Hyaluronic Acid, Prolotherapy with Dextrose and Physical Therapy in Knee Osteoarthritis

Comparsion between Therapeutic Effects of Intra-articular Botulinum Neurotoxin , Hyaluronic Acid, Prolotherapy with Dextrose and Physical Therapy in Knee Osteoarthritis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20181217042028N2
Enrollment
120
Registered
2019-04-18
Start date
2018-06-22
Completion date
Unknown
Last updated
2019-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis. Unilateral primary osteoarthritis of knee

Interventions

Intervention 1: First Intervention group: Intra-articular injection of Botulinum Toxin at the knee. Intervention 2: Second Intervention group: Intra-articular injection of Hyaluronic Acid at the knee.

Sponsors

Artesh University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to No maximum

Inclusion criteria

Inclusion criteria: Age older than 50 Crepitus or morning stiffness for less than 30 minutes Radiographic finding Symptoms longer than 3 monthes

Exclusion criteria

Exclusion criteria: Patient dissatisfaction The presence of other knee joint diseases History of surgery in the desired joint History of fracture in knee bones Intra-articular corticosteroid injection in the last 2 weeks Contraindication of intera-articular injection Immunodeficeincy Sensitivity to botulinum toxin Dysfunction of the lower extremity due to neurological or internal medicine

Design outcomes

Primary

MeasureTime frame
Pain Severity based on Visual Analogue Scale. Timepoint: Before intervention, one and three months later. Method of measurement: Visual Analogue Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Abdorrazaghi

Artesh University of Medical Sciences

z.rezasoltani@ajaums.ac.ir+98 21 6652 1827

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026