Skip to content

The effect of two kinds of triggering with GnRh agonist in antagonist protocol

A comparison between the effect of two kinds of triggering with GnRh agonist in PCOS patients treated by antagonist protocol for ART on oocyte and embryo quality

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20181211041930N1
Enrollment
120
Registered
2018-12-22
Start date
2018-12-10
Completion date
Unknown
Last updated
2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Triggering with different doses of GnRh a in PCO patients. Female infertility, unspecified

Interventions

Intervention 1: Intervention group: The intervention group were triggered by injection of decapeptyl 0.2 mg, following by the second dose of decapeptyl 0.1 mg after 12 hours. Intervention 2: Control

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 38 Years

Inclusion criteria

Inclusion criteria: PCOS women based on Rotterdam criteria who were candidate for ART Serum estradiol level more than 3000 pg/ml on triggering day Ovarian stimulation with GnRH antagonist protocol Age between 20-38 years Body Mass Index > 18 and < 30

Exclusion criteria

Exclusion criteria: Sever endometriosis Sever male factor infertility Uterine anomaly Metabolic disease

Design outcomes

Primary

MeasureTime frame
The number of mature oocytes (MII). Timepoint: After oocyte retrieval. Method of measurement: Counting mature oocyte under microscopy.;Number of 2PNs. Timepoint: 16 hours After fertilization. Method of measurement: Counting 2PNs under microscopy.;OHSS developing. Timepoint: Days 4 and 7 post oocyte pick-up. Method of measurement: Measuring ovarian size, presence of free fluid in Douglas.

Secondary

MeasureTime frame
Embryos quality and embryo count. Timepoint: 48 hours after fertilization. Method of measurement: Assessment under microscopy by embryologist.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasrooreh Hoseini

Yazd University of Medical Sciences

masroorehoseini@yahoo.com+98 35 3824 7085

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026