The effect of Nigella sativa oil and Dichlophenac Gel on the reduction of knee Osteoarthritis pain

Comparison the effect of Nigella sativa oil and Dichlophenac Gel on the reduction of knee pain in patient with Osteoarthritis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181211041923N1

Enrollment

Registered

2019-07-14

Start date

2019-01-30

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with knee osteoarthritis based on clinical and radiological criteria of the American College of Rheumatology (ACR = 2_3). Osteopathies and chondropathies

Interventions

Intervention 1: Intervention group: rub one gram of nigella sativa oil on a knee every six hours for three weeks. Intervention 2: Control group: rub one gram diclofenac gel on a knee every six hours f

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patiant with knee osteoarthritis based on ACR=2_3 and clinical standard Satisfaction to enter the study

Exclusion criteria

Exclusion criteria: Joint effusion Arthritis Liver and kidney failure Consumption of neurological drugs

Design outcomes

Primary

Measure	Time frame
Pain based on the Visual Analogue Scale (VAS). Timepoint: At the beginning of the study (before the intervention) and 3 weeks after starting the drug administration. Method of measurement: Visual Analogue Scale.	—

Secondary

Measure	Time frame
The intensity of osteoarthritis based on the KellgreneLawrence scale. Timepoint: At the beginning of the study (before the intervention) and 3 weeks after starting the drug administration. Method of measurement: KellgreneLawrence scale.;Patients knee conditions based on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Timepoint: At the beginning of the study (before the intervention) and 3 weeks after starting the drug administration. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).	—

Measure

Time frame

The intensity of osteoarthritis based on the KellgreneLawrence scale. Timepoint: At the beginning of the study (before the intervention) and 3 weeks after starting the drug administration. Method of measurement: KellgreneLawrence scale.;Patients knee conditions based on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Timepoint: At the beginning of the study (before the intervention) and 3 weeks after starting the drug administration. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahnaz Sandooghi

Zahedan University of Medical Sciences

Mahnazsandooghi@yahoo.com+98 54 3329 5796

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026