Evaluation of the effect of topical sildenafil and diltiazem gel in the treatment of fissures

Evaluation and comparison of the effect of sildenafil topical cream 10% and diltiazem gel 2%in the treatment of anal fissure

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181208041882N7

Enrollment

Registered

2022-05-07

Start date

2019-04-21

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anal fissure. Anal fissure, unspecified

Interventions

Intervention 1: Intervention group: : Sildenafil topical cream receives 10% 3 times a day for a week intra-anal patient Made in Yazd University of Medical Sciences. Intervention 2: Intervention group:

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 18 to 65 years Having symptoms includes pain after defecation bleeding or both

Exclusion criteria

Exclusion criteria: Recurrent fissure Fissures in an unusual position No pain

Design outcomes

Primary

Measure	Time frame
Onset of pain reduction. Timepoint: This variable was measured after each use of the drug by the patient. Method of measurement: Based on questions from the patient.;Maximum relaxation time. Timepoint: This variable was measured after each use of the drug by the patient. Method of measurement: Visual Analogue Scale.;Duration of treatment. Timepoint: After complete consumption of the drug by the patient and complete recovery. Method of measurement: Based on questions from the patient.;The length of the recovery period. Timepoint: After taking the drug by the patient and that the patient notices a reduction in symptoms after a few days. Method of measurement: Based on questions from the patient.	—

Measure

Time frame

Onset of pain reduction. Timepoint: This variable was measured after each use of the drug by the patient. Method of measurement: Based on questions from the patient.;Maximum relaxation time. Timepoint: This variable was measured after each use of the drug by the patient. Method of measurement: Visual Analogue Scale.;Duration of treatment. Timepoint: After complete consumption of the drug by the patient and complete recovery. Method of measurement: Based on questions from the patient.;The length of the recovery period. Timepoint: After taking the drug by the patient and that the patient notices a reduction in symptoms after a few days. Method of measurement: Based on questions from the patient.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehrooz Heydari

Yazd University of Medical Sciences

b.heydari@ssu.ac.ir+98 35 3830 3410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026