Topical N-Acetylcysteine and Zinc Oxide in the Treatment of Diaper Dermatitis

Comparison of the Effectiveness of Topical N-Acetylcysteine and Zinc Oxide in the Treatment of Diaper Dermatitis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181208041882N6

Enrollment

Registered

2022-01-09

Start date

2019-06-22

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diaper Dermatitis. Diaper dermatitis

Interventions

Intervention 1: Intervention group: After 3% N-acetylcysteine cream formulation, use topically after each diaper change for 5 days. Intervention 2: Control group: Topical zinc oxide ointment 20% (Casp

Eligibility

Sex/Gender

All

Age

No minimum to 2 Years

Inclusion criteria

Inclusion criteria: Patients aged less than 2 years Diagnosed with diaper dermatitis

Exclusion criteria

Exclusion criteria: Secondary infectious dermatitis Use of any corticosteroid A history of atopic dermatitis, candidiasis, or seborrheic dermatitis Birth defect

Design outcomes

Primary

Measure	Time frame
Evaluation of erythema severity. Timepoint: Days one, three and five after the intervention. Method of measurement: Based on scoring the severity of diaper dermatitis scale.	—

Secondary

Measure	Time frame
Patients' recovery compared to the first day of intervention. Timepoint: The first, third and fifth day after intervention. Method of measurement: Observation and comparison of erythema severity, extent of dermatitis and clinical manifestations.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehrooz Heydari

Yazd University of Medical Sciences

b.heydari@ssu.ac.ir+98 35 3820 3410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026