Evaluation of Curcumin effevtiveness in prophylaxis of renal toxicity

Evaluation of Curcumin effevtiveness in prophylaxis of Cisplatin induced renal toxicity

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181208041882N4

Enrollment

Registered

2021-09-26

Start date

2020-11-21

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nephrotoxicity caused by cisplatin injection.

Interventions

Intervention 1: Patients start taking curcumin capsules (500mg, Karen company) orally twice daily from two days before cisplatin injection and continue for 4 days. Intervention 2: Control group:Patien

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients 18 to 80 years old to get started chemotherapy with Cisplatin The patient satisfaction

Exclusion criteria

Exclusion criteria: Active infection Heart failure Liver failure Taking other nephrotoxic drugs

Design outcomes

Primary

Measure	Time frame
Measurement Mg Urinary Random. Timepoint: Two days before and two days after Cisplatin injection. Method of measurement: Laboratory data.;Measurement Ca Urinary Random. Timepoint: two Days before and two Days after Cisplatin injection. Method of measurement: Laboratory data.;Measurement Na Urinary Random. Timepoint: two Days before and two Days after Cisplatin injection. Method of measurement: Laboratory data.;Measurement K Urinary Random. Timepoint: two Days before and two Days after Cisplatin injection. Method of measurement: Laboratory data.;Measurement of urinary protein NGAL (Neutrophil gelatinase-associated lipocalin) . In acute kidney damage, the protein is released from the damaged kidney cells after 2 hours and enters the urine. Timepoint: Measurement of urinary NGAL two days before and two days after cisplatin injection. Method of measurement: Based on the ELISA diagnostic kit.	—

Measure

Time frame

Measurement Mg Urinary Random. Timepoint: Two days before and two days after Cisplatin injection. Method of measurement: Laboratory data.;Measurement Ca Urinary Random. Timepoint: two Days before and two Days after Cisplatin injection. Method of measurement: Laboratory data.;Measurement Na Urinary Random. Timepoint: two Days before and two Days after Cisplatin injection. Method of measurement: Laboratory data.;Measurement K Urinary Random. Timepoint: two Days before and two Days after Cisplatin injection. Method of measurement: Laboratory data.;Measurement of urinary protein NGAL (Neutrophil gelatinase-associated lipocalin) . In acute kidney damage, the protein is released from the damaged kidney cells after 2 hours and enters the urine. Timepoint: Measurement of urinary NGAL two days before and two days after cisplatin injection. Method of measurement: Based on the ELISA diagnostic kit.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehrooz Heydari

Yazd University of Medical Sciences

b.heydari@ssu.ac.ir+98 35 3820 3410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026