The effect of probiotics in the treatment of acne vulgaris

Investigating the effectiveness of probiotics compared to placebo in the treatment of acne vulgaris with moderate severity: a randomized double-blind clinical trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181208041882N21

Enrollment

Registered

2025-05-03

Start date

2019-01-21

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne vulgaris. Acne vulgaris

Interventions

Intervention 1: Intervention group: For 12 weeks, patients receive 2 probiotic capsules containing lactobacillus and bifidobacterium from Zist Takhmir Company. All patients will receive adapalene crea

Eligibility

Sex/Gender

All

Age

18 Years to 42 Years

Inclusion criteria

Inclusion criteria: Patients aged 18 to 42 years with moderate acne vulgaris

Exclusion criteria

Exclusion criteria: Pregnancy Breast feeding Autoimmune disease Patients receiving isotretinoin Patients who have changed their contraceptive pill in the last 3 months Probiotic consumption in the last month

Design outcomes

Primary

Measure	Time frame
Acne severity. Timepoint: Start of study, fourth and twelfth week. Method of measurement: The number of lesions (comedone, papule and pustule).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehrooz Heydari

Yazd University of Medical Sciences

b.heydari@ssu.ac.ir+98 35 3820 3410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026