Evaluation and Comparison the effects of amitriptyline, ibuprofen and placebo in patients with irreversible pulpitis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181208041882N2

Enrollment

Registered

2020-07-04

Start date

2018-08-23

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

irreversible pulpitis.

Interventions

Intervention 1: Intervention group: Amitriptyline 25mg, 1 or 2 hours before injecting the Anesthetic drug,patient receive one of the same capsules orally.manufactured by Daru Pakhsh. Intervention 2: I

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Healthy candidates with no specific systemic diseases(specially heart,hepatic and renal diseases) Do not use any analgesic drugs within 4 hours before referral Diagnosis of irreversible pulpitis based on pulp vitality tests

Exclusion criteria

Exclusion criteria: Using analgesic drugs before refer Medical allergy to NSAIDs and Amitriptyline Teeth with a history of trauma and teeth that have recently been endodontically or orthodontically experienced in the last 6 months Pregnancy and Lactation

Design outcomes

Primary

Measure	Time frame
Reduction in patient pain score. Timepoint: Pain score on presentation,Pain score during injection,Pain score during procedure,Pain score at home(the first 6-8 hours ). Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactbehrooz heydari

Yazd University of Medical Sciences

b.heydari@ssu.ac.ir+98 35 3820 3410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026