The effect of topical cholestyramine in the treatment of diaper dermatitis

Comparison of topical cholestyramine and zinc oxide in the treatment of diaper dermatitis from diarrhea: a randomized, double-blind clinical trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181208041882N19

Enrollment

Registered

2023-11-05

Start date

2017-12-22

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diaper rash. Diaper dermatitis

Interventions

Intervention 1: Intervention group: 5% cholestyramine cream formulation (manufactured in Yazd Faculty of Pharmacy), use topically after each diaper change for 5 days. Intervention 2: Control group: T

Eligibility

Sex/Gender

All

Age

No minimum to 24 Months

Inclusion criteria

Inclusion criteria: Age less than 24 months Diaper dermatitis in children with diarrhea

Exclusion criteria

Exclusion criteria: Skin diseases, kidney diseases, birth defects, oral or genital candidiasis Use of other drugs to treat diaper dermatitis Use of topical antibiotics in the area of diaper dermatitis

Design outcomes

Primary

Measure	Time frame
Erythema severity. Timepoint: Days one, three and five after the intervention. Method of measurement: Based on scoring the severity of diaper dermatitis scale.	—

Secondary

Measure	Time frame
Patients' recovery compared to the first day of intervention. Timepoint: The first, third and fifth day after intervention. Method of measurement: Observation and comparison of erythema severity, extent of dermatitis and clinical manifestations.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehrooz Heydari

Yazd University of Medical Sciences

b.heydari@ssu.ac.ir+98 35 3820 3410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026