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The effect of vitamin E in the treatment of radiotherapy dermatitis

Evaluation of Topical vitamin E and zinc oxide versus zinc oxide in treatment of radiation dermatitis: a double-blind clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20181208041882N14
Enrollment
56
Registered
2023-10-16
Start date
2018-04-21
Completion date
Unknown
Last updated
2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dermatitis caused by breast radiation therapy. Radiodermatitis

Interventions

Intervention 1: Intervention group: The patient receives topical ointment of vitamin E 18% and zinc oxide 20% (manufactured in Yazd Faculty of Pharmacy) twice daily from the first day of radiation the

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with grade 1 to 2 skin dermatitis caused by radiotherapy Patients aged 18 to 65 years

Exclusion criteria

Exclusion criteria: Patients with skin disease hypersensitivity to vitamin E or zinc oxide Severe systemic disease such as uncontrolled diabetes

Design outcomes

Primary

MeasureTime frame
Intensity of redness. Timepoint: Weeks 0, 1, 2, 3, 4. Method of measurement: RTOG standard scale.;Itching intensity. Timepoint: Weeks 0,1,2,3,4. Method of measurement: Based on visual analog scale.;Intensity of burning. Timepoint: Weeks 0,1,2,3,4. Method of measurement: Based on visual analog scale.;Intensity of pain. Timepoint: Weeks 0,1,2,3,4. Method of measurement: Based on visual analog scale.—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehrooz Heydari

Yazd University of Medical Sciences

b.heydari@ssu.ac.ir+98 35 3820 3410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026