N-acetylcysteine in the treatment of diarrhea caused by rotavirus

Evaluation of N-acetylcysteine efficacy compared to placebo in the treatment of diarrhea caused by rotavirus in children: a randomized, double-blind clinical trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181208041882N13

Enrollment

Registered

2023-10-14

Start date

2017-04-21

Completion date

Unknown

Last updated

2023-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diarrhea caused by rotavirus. Rotaviral enteritis

Interventions

Intervention 1: Intervention group: Patients aged 6 months to 5 years with diarrhea caused by rotavirus receive 60 mg/kg N-acetylcysteine syrup daily (prepared at Yazd Faculty of Pharmacy) in 3 divide

Eligibility

Sex/Gender

All

Age

6 Months to 5 Years

Inclusion criteria

Inclusion criteria: Rotavirus infection has been confirmed in patient. The age range of the patient is between 6 months and 5 years Absence of genetic or chronic diseases in patients Insensitivity to N-acetylcysteine Do not receive ibuprofen

Exclusion criteria

Exclusion criteria: Patients who refer after 48 hours from the onset of diarrhea. Patients who receive ibuprofen. Hypersensitivity to N-acetylcysteine

Design outcomes

Primary

Measure	Time frame
Investigation of duration and frequency of diarrhea. Timepoint: Days zero to seven. Method of measurement: Frequency of diarrhea per day and duration of diarrhea.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehrooz Heydari

Yazd University of Medical Sciences

b.heydari@ssu.ac.ir+98 35 3820 3410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 5, 2026