The effect of ondansetron in reducing capsaicin inflammation

Evaluation of ondansetron efficacy in reducing capsaicin-induced inflammation: a randomized crossover clinical trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181208041882N11

Enrollment

Registered

2023-10-10

Start date

2020-02-20

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation caused by capsaicin.

Interventions

Intervention 1: Intervention group 1: Volunteers use a cream containing 0.075% capsaicin and 0.75% ondansetron (manufactured in Yazd Faculty of Pharmacy) for 3 days and 4 times a day on their knees. I

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age above 18 years Insensitivity to capsaicin

Exclusion criteria

Exclusion criteria: Hypersensitivity to capsaicin Pregnancy Breastfeeding Occurrence of side effects during the study

Design outcomes

Primary

Measure	Time frame
Intensity and duration of capsaicin-induced burning. Timepoint: Days 1, 2 and 3. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehrooz Heydari

Yazd University of Medical Sciences

b.heydari@ssu.ac.ir+98 35 3820 3410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026