Effect of Doxepin rinse and Persica mouthwash in mucositis pain

Investigating the effect of Doxepin 0.5% mouthwash in comparison with Persica mouthwash on reducing the pain of oral mucositis in patients with head and neck cancer after radiotherapy and chemotherapy

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20181208041882N1

Enrollment

Registered

2020-03-24

Start date

2018-04-21

Completion date

Unknown

Last updated

2020-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral mucositis. Oral mucositis (ulcerative) due to radiation

Interventions

Intervention 1: Intervention group: Persika Mouthwash, 5 cc, 3 times a day,1minute. Duration of study: 24 hours, manufactured by Poursina. Intervention 2: Control group: Doxepine mouthwash 0.5%, 5c

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients who received more than 45 gray of radiation and had mucositis and their pain score was more than 4 on the basis of the Visual Analogue Scale Age more than 18 years old

Exclusion criteria

Exclusion criteria: Sensitivity to TCA drugs Taking TCA or MAO inhibitors in the last 2 weeks Candidiasis infection or oral herpes Untreated open angle glaucoma Untreated urination retention in the past 6 weeks

Design outcomes

Primary

Measure	Time frame
Reduction patient pain score. Timepoint: 5, 15, 30, 60, 120, 240 minutes and 24 hours after applying mouthwash. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehrooz Heydari

Yazd University of Medical Sciences

b.heydai@ssu.ac.ir+98 35 3820 8699

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026