Patients with maxillofacial bone defects. Hypertrophy of bone
Conditions
Interventions
Intervention 1: Intervention group: Patients with oral maxillofacial bone defect who receive autologous mononuclear cells isolated from adipose tissue with bone scaffolds (routine treatment) through o
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The patient has a bone defect in the maxillofacial region
Exclusion criteria
Exclusion criteria: The defect should not be socket, dehiscence, fenestration, and also sinus not involved. systemic and metabolic diseases active infection compromised immune system pregnant and or lactating women osteoporosis and osteopetrosis previous alveolar surgery smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In this study, safety is the main primary outcome. Timepoint: The patient will be visited one and six days as well as 1 and 6 months after surgery. But during this time, if patients have any abnormal clinical symptoms, you will be counseled or visited by telephone or in person. Method of measurement: To evaluate the safety, different parameters such as infection, inflammation, fibrosis tissue formation, local edema, local erythema, pain, dental implant rejection, dental sensitivity, and mortality will be evaluated through clinical evaluations, blood tests, CT scans Conical scans and scatological analyzes. | — |
Secondary
| Measure | Time frame |
|---|---|
| New bone formation. Timepoint: after 6 months from surgery. Method of measurement: analysis of Cone Beam-CT data and histology images. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahboubeh Bohlouli
Shahid Beheshti University of Medical Sciences
Outcome results
None listed